Aneurin (vitamin B1) and pyruvate metabolism by Staphylococcus aureus
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چکیده
منابع مشابه
The Vitamin B1 Metabolism of Staphylococcus aureus Is Controlled at Enzymatic and Transcriptional Levels
Vitamin B1 is in its active form thiamine pyrophosphate (TPP), an essential cofactor for several key enzymes in the carbohydrate metabolism. Mammals must salvage this crucial nutrient from their diet in order to complement the deficiency of de novo synthesis. In the human pathogenic bacterium Staphylococcus aureus, two operons were identified which are involved in vitamin B1 metabolism. The fir...
متن کاملLxxx. Blood Pyruvate in Vitamin B1 Deficiency
IN the course of recent work on the role of vitamin B, in the metabolism of brain, it was discovered [Peters and Sinclair, 1933] that lactate solutions in which avitaminous pigeon's brain cells had respired for 2 hours gave a positive nitroprusside reaction for pyruvic acid [Simon and Piaux, 1924]. This led to a quantitative investigation of the formation of pyruvic acid during the respiration ...
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The resurgence of interest in cancer metabolism has linked alterations in the regulation and exploitation of metabolic pathways with an anabolic phenotype that increases biomass production for the replication of new daughter cells. To support the increase in the metabolic rate of cancer cells, a coordinated increase in the supply of nutrients, such as glucose and micronutrients functioning as e...
متن کاملThe localization of aneurin pyrophosphatase in the brain.
Vitamin B1 is nearly exclusively present in animal tissues as aneurin pyrophosphate (Ochoa and Peters, 1938). The vitamin is first converted to aneurin pyrophosphate by the tissues and in this form it enables the oxidative decarboxylation of pyruvic acid to take place allowing glucose metabolism to go beyond the pyruvate stage (Banga, Ochoa, and Peters, 1939). It has been shown more recently th...
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As a leading cause of community-associated and nosocomial infections, Staphylococcus aureus requires sophisticated mechanisms that function to maintain cellular homeostasis in response to its exposure to changing environmental conditions. The adaptation to stress and maintenance of homeostasis depend largely on membrane activity, including supporting electrochemical gradients and synthesis of A...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1938
ISSN: 0306-3283
DOI: 10.1042/bj0320383